Skip to main content

ASU Global menu

Skip to Content Report an accessibility problem ASU Home My ASU Colleges and Schools Sign In
Arizona State University Arizona State University
ASU Library KEEP

Main navigation

Home Browse Collections Share Your Work
Copyright Describe Your Materials File Formats Open Access Repository Practices Share Your Materials Terms of Deposit API Documentation
Skip to Content Report an accessibility problem ASU Home My ASU Colleges and Schools Sign In
  1. KEEP
  2. Theses and Dissertations
  3. ASU Electronic Theses and Dissertations
  4. Genetic influences on the dynamics of pain and affect in fibromyalgia
  5. Full metadata

Genetic influences on the dynamics of pain and affect in fibromyalgia

Full metadata

Description

Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.

Date Created
2011
Contributors
  • Finan, Patrick Hamilton (Author)
  • Zautra, Alex (Thesis advisor)
  • Davis, Mary (Committee member)
  • Lemery-Chalfant, Kathryn (Committee member)
  • Presson, Clark (Committee member)
  • Arizona State University (Publisher)
Topical Subject
  • psychology
  • Genetics
  • Affect
  • Dopamine
  • Fibromyalgia
  • Genetics
  • Opioids
  • Pain
  • Fibromyalgia--Psychological aspects.
  • Fibromyalgia
  • Fibromyalgia--Genetic aspects.
  • Fibromyalgia
Resource Type
Text
Genre
Doctoral Dissertation
Academic theses
Extent
ix, 100 p. : ill
Language
eng
Copyright Statement
In Copyright
Reuse Permissions
All Rights Reserved
Primary Member of
ASU Electronic Theses and Dissertations
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.I.9516
Embargo Release Date
Thu, 02/06/2014 - 16:55
Statement of Responsibility
Patrick Hamilton Finan
Description Source
Viewed on June 26, 2012
Level of coding
full
Note
Partial requirement for: Ph. D., Arizona State University, 2011
Note type
thesis
Includes bibliographical references (p
Field of study: Psychology
System Created
  • 2011-09-22 01:51:59
System Modified
  • 2021-08-30 01:50:47
  •     
  • 1 year 6 months ago
Additional Formats
  • OAI Dublin Core
  • MODS XML

Quick actions

About this item

Overview
 Copy permalink

Explore this item

Explore Document

Share this content

Feedback

ASU University Technology Office Arizona State University.
KEEP

Contact Us

Repository Services
Home KEEP PRISM ASU Research Data Repository
Resources
Terms of Deposit Sharing Materials: ASU Digital Repository Guide Open Access at ASU

The ASU Library acknowledges the twenty-three Native Nations that have inhabited this land for centuries. Arizona State University's four campuses are located in the Salt River Valley on ancestral territories of Indigenous peoples, including the Akimel O’odham (Pima) and Pee Posh (Maricopa) Indian Communities, whose care and keeping of these lands allows us to be here today. ASU Library acknowledges the sovereignty of these nations and seeks to foster an environment of success and possibility for Native American students and patrons. We are advocates for the incorporation of Indigenous knowledge systems and research methodologies within contemporary library practice. ASU Library welcomes members of the Akimel O’odham and Pee Posh, and all Native nations to the Library.

Number one in the U.S. for innovation. ASU ahead of MIT and Stanford. - U.S. News and World Report, 8 years, 2016-2023
Maps and Locations Jobs Directory Contact ASU My ASU
Copyright and Trademark Accessibility Privacy Terms of Use Emergency COVID-19 Information