We constructed an 11-arm, walk-through, human radial-arm maze (HRAM) as a translational instrument to compare existing methodology in the areas of rodent and human learning and memory research. The HRAM, utilized here, serves as an intermediary test between the classic rat radial-arm maze (RAM) and standard human neuropsychological and cognitive tests. We show that the HRAM is a useful instrument to examine working memory ability, explore the relationships between rodent and human memory and cognition models, and evaluate factors that contribute to human navigational ability.
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- Digital object identifier: 10.3389/fnbeh.2014.00294
- Identifier TypeInternational standard serial numberIdentifier Value1662-5153
- The article as published can be viewed at http://journal.frontiersin.org/journal/10.3389/fnbeh.2014.00294/full, opens in a new window
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Mennenga SE, Baxter LC, Grunfeld IS, Brewer GA, Aiken LS, Engler-Chiurazzi EB, Camp BW, Acosta JI, Braden BB, Schaefer KR, Gerson JE, Lavery CN, Tsang CWS, Hewitt LT, Kingston ML, Koebele SV, Patten KJ, Ball BH, McBeath MK and Bimonte-Nelson HA (2014) Navigating to new frontiers in behavioral neuroscience: traditional neuropsychological tests predict human performance on a rodent-inspired radial-arm maze. Front. Behav. Neurosci. 8:294. doi: 10.3389/fnbeh.2014.00294