Description

This manuscript reviews biological abnormalities shared by autism spectrum disorder (ASD) and epilepsy. Two neuropathological findings are shared by ASD and epilepsy: abnormalities in minicolumn architecture and γ-aminobutyric acid (GABA)

This manuscript reviews biological abnormalities shared by autism spectrum disorder (ASD) and epilepsy. Two neuropathological findings are shared by ASD and epilepsy: abnormalities in minicolumn architecture and γ-aminobutyric acid (GABA) neurotransmission. The peripheral neuropil, which is the region that contains the inhibition circuits of the minicolumns, has been found to be decreased in the post-mortem ASD brain. ASD and epilepsy are associated with inhibitory GABA neurotransmission abnormalities including reduced GABA[subscript A] and GABA[subscript B] subunit expression.

Reuse Permissions
  • 200.69 KB application/pdf

    Download count: 0

    Details

    Date Created
    • 2016-05-10
    Resource Type
  • Text
  • Collections this item is in
    Identifier
    • Digital object identifier: 10.3389/fnins.2016.00192
    • Identifier Type
      International standard serial number
      Identifier Value
      0269-8463
    • Identifier Type
      International standard serial number
      Identifier Value
      1365-2435

    Citation and reuse

    Cite this item

    This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.

    Frye, R. E., Casanova, M. F., Fatemi, S. H., Folsom, T. D., Reutiman, T. J., Brown, G. L., . . . Adams, J. B. (2016). Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder. Frontiers in Neuroscience, 10. doi:10.3389/fnins.2016.00192

    Machine-readable links