This manuscript reviews biological abnormalities shared by autism spectrum disorder (ASD) and epilepsy. Two neuropathological findings are shared by ASD and epilepsy: abnormalities in minicolumn architecture and γ-aminobutyric acid (GABA) neurotransmission. The peripheral neuropil, which is the region that contains the inhibition circuits of the minicolumns, has been found to be decreased in the post-mortem ASD brain. ASD and epilepsy are associated with inhibitory GABA neurotransmission abnormalities including reduced GABA[subscript A] and GABA[subscript B] subunit expression.
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- Digital object identifier: 10.3389/fnins.2016.00192
- Identifier TypeInternational standard serial numberIdentifier Value0269-8463
- Identifier TypeInternational standard serial numberIdentifier Value1365-2435
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Frye, R. E., Casanova, M. F., Fatemi, S. H., Folsom, T. D., Reutiman, T. J., Brown, G. L., . . . Adams, J. B. (2016). Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder. Frontiers in Neuroscience, 10. doi:10.3389/fnins.2016.00192