ABSTRACT Telomeres are vital in protecting chromosome ends to prevent telomere shortening. Telomerase is a ribonucleoprotein responsible for adding telomere repeats and maintaining telomere length. Telomerase holoenzyme consists of 2 major subcomponents: telomerase reverse transcriptase (TERT) and telomerase RNA (TR). The catalytic subunit is TERT and the subunit that adds deoxyribonucleotide to the ends of chromosome is TR. TR contains an alignment portion and a template portion.
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