134963-Thumbnail Image.png
Description

Genetically encoded non-canonical amino acids (NCAAs) have allowed researchers to access functionalities that would be otherwise unavailable with the naturally-occurring amino acids. The metal-chelating NCAA (2,2'-bipyridin-5yl)alanine (Bpy-ala) has recently been

Genetically encoded non-canonical amino acids (NCAAs) have allowed researchers to access functionalities that would be otherwise unavailable with the naturally-occurring amino acids. The metal-chelating NCAA (2,2'-bipyridin-5yl)alanine (Bpy-ala) has recently been employed, in tandem with computational modeling, to drive the assembly of a homotrimeric protein complex in the presence of a metal ion, specifically Fe(II). While a successful design was identified to form a homotrimeric complex with an iron-trisbipyridyl [Fe(Bpy-ala)3]2+ core when expressed in E.

9.59 MB application/pdf

Download restricted. Please sign in.

Download count: 0

Details

Contributors
Date Created
  • 2017-05
Resource Type
  • Text
  • Note
    • A copy of this thesis/creative project may be available at Barrett, the Honors College at Arizona State University. If you would like to access the printed copy, please email thesis@asu.edu, opens in a new window

    Machine-readable links