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  1. KEEP
  2. Theses and Dissertations
  3. Barrett, The Honors College Thesis/Creative Project Collection
  4. Toxin Level Analysis in Dogs Envenomated by Pit Vipers in Arizona
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Toxin Level Analysis in Dogs Envenomated by Pit Vipers in Arizona

Full metadata

Description

To date, there have been few, if any, studies evaluating the venom toxin levels in dogs that have been naturally envenomated by pit vipers. Understanding venom toxin pharmacokinetics in a clinical setting is important for a variety of reasons, including the potential to better elucidate treatment options, prognosis, and other factors associated with pit viper envenomation. In addition, dogs serve as a comparative species to humans for evaluating pit viper envenomations. This pilot study’s primary objective was to address the question of “What do we see?” in dogs presenting for rattlesnake envenomation. To answer this question, we obtained serum from envenomated dogs presenting at three veterinary clinics, then used enzyme-linked immunosorbent assay (ELISA) and western blot analysis to measure total venom and key toxins in sera. Phospholipase A2, a primary venom toxin, was identified in a few samples by the western blot, and contributed to the positive correlation between percent echinocytes in the blood and venom concentration. Medical data records were compared to venom concentrations measured using ELISA to determine whether there were any significant correlations. First, the hematological results were compared. Clotting times showed a strong positive correlation, clotting times and platelets showed a negative correlation, while echinocytes and platelets showed no correlation. When compared to venom concentration, clotting times showed a negative correlation, while age showed a positive correlation. Weight and platelets were also compared to venom concentration, but no significant correlations were found. The logistics of this study provided a real-world model where time elapsed between envenomation and hospital admission, thus giving a realistic look at what occurs in both animal and human medicine.

Date Created
2019-05
Contributors
  • Nelson, Alexis (Co-author, Co-author)
  • DeNardo, Dale (Thesis director)
  • Woods, Craig (Thesis director)
  • Varsani, Arvind (Committee member)
  • Harrington Bioengineering Program (Contributor)
  • Barrett, The Honors College (Contributor)
Topical Subject
  • Veterinary Medicine
  • Rattlesnake
  • Venom
  • Dogs
Resource Type
Text
Extent
18 pages
Language
eng
Copyright Statement
In Copyright
Primary Member of
Barrett, The Honors College Thesis/Creative Project Collection
Series
Academic Year 2018-2019
Handle
https://hdl.handle.net/2286/R.I.52812
Level of coding
minimal
Cataloging Standards
asu1
System Created
  • 2019-04-20 12:00:19
System Modified
  • 2021-08-11 04:09:57
  •     
  • 1 year 7 months ago
Additional Formats
  • OAI Dublin Core
  • MODS XML

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