Description
Serotonin 2A receptor (5-HT2AR) levels are decreased in the brains of schizophrenia patients. This phenomenon is modeled in mice that lack the transcription factor Egr3. The head-twitch response (HTR) is a behavioral assay used to assess the physiological function of 5-HT2ARs. However, current quantification methods are time consuming and prone to inter-rater variability. Here, we demonstrate the validity and reliability of an automated head-twitch system to quantify HTRs of Egr3-/- mice.
Details
Title
- Creation and Validation of an Automated Head Twitch Analysis Instrument to Study a Mouse Model of Psychosis
Contributors
- Ozols, Annika Biruta (Author)
- Lisenbee, Cayle S. (Thesis director)
- Gallitano, Amelia L. (Committee member)
- College of Health Solutions (Contributor)
- Barrett, The Honors College (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2020-05
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