Background: HIV-1 Clade C (Subtype C; HIV-1C) is responsible for greater than 50% of infections worldwide. Unlike clade B HIV-1 (Subtype B; HIV-1B), which is known to cause HIV associated dementia (HAD) in approximately 15% to 30% of the infected individuals, HIV-1C has been linked with lower prevalence of HAD (0 to 6%) in India and Ethiopia. However, recent studies report a higher prevalence of HAD in South Africa, Zambia and Botswana, where HIV-1C infections predominate. Therefore, we examined whether Southern African HIV-1C is genetically distinct and investigated its neurovirulence.
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- Rao, Vasudev R. (Author)
- Neogi, Ujjwal (Author)
- Talboom, Joshua (Contributor)
- Padilla, Ligia (Author)
- Rahman, Mustafizur (Author)
- Fritz-French, Cari (Author)
- Gonzalez-Ramirez, Sandra (Author)
- Verma, Anjali (Author)
- Wood, Charles (Author)
- Ruprecht, Ruth M (Author)
- Ranga, Udaykumar (Author)
- Azim, Tasnim (Author)
- Joska, John (Author)
- Eugenin, Eliseo (Author)
- Shet, Anita (Author)
- Bimonte-Nelson, Heather (Contributor)
- Tyor, William R. (Author)
- Prasad, Vinayaka R. (Author)
- College of Liberal Arts and Sciences (Contributor)
- 2013-08-30
- Digital object identifier: 10.1186/1742-4690-10-61
- Identifier TypeInternational standard serial numberIdentifier Value1742-4690
- This electronic version of this article is the complete one and can also be found online at: http://www.retrovirology.com/content/10/1/61, opens in a new window
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Rao et al.: Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motifcontaining Tat variants than those in Southeast Asia and cause increased neurovirulence. Retrovirology 2013 10:61.