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Background: HIV-1 Clade C (Subtype C; HIV-1C) is responsible for greater than 50% of infections worldwide. Unlike clade B HIV-1 (Subtype B; HIV-1B), which is known to cause HIV associated

Background: HIV-1 Clade C (Subtype C; HIV-1C) is responsible for greater than 50% of infections worldwide. Unlike clade B HIV-1 (Subtype B; HIV-1B), which is known to cause HIV associated dementia (HAD) in approximately 15% to 30% of the infected individuals, HIV-1C has been linked with lower prevalence of HAD (0 to 6%) in India and Ethiopia. However, recent studies report a higher prevalence of HAD in South Africa, Zambia and Botswana, where HIV-1C infections predominate. Therefore, we examined whether Southern African HIV-1C is genetically distinct and investigated its neurovirulence.

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    Date Created
    • 2013-08-30
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    • Digital object identifier: 10.1186/1742-4690-10-61
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      International standard serial number
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      1742-4690
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    Rao et al.: Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motifcontaining Tat variants than those in Southeast Asia and cause increased neurovirulence. Retrovirology 2013 10:61.

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