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The apolipoprotein E (APOE) e4 allele is the most prevalent genetic risk factor for Alzheimer's disease (AD). Hippocampal volumes are generally smaller in AD patients carrying the e4 allele compared

The apolipoprotein E (APOE) e4 allele is the most prevalent genetic risk factor for Alzheimer's disease (AD). Hippocampal volumes are generally smaller in AD patients carrying the e4 allele compared to e4 noncarriers. Here we examined the effect of APOE e4 on hippocampal morphometry in a large imaging database—the Alzheimer's Disease Neuroimaging Initiative (ADNI).

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Date Created
  • 2014-08-01
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  • Text
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    Identifier
    • Digital object identifier: 10.1002/hbm.22447
    • Identifier Type
      International standard serial number
      Identifier Value
      1097-0193
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    Shi, Jie, Lepore, Natasha, Gutman, Boris A., Thompson, Paul M., Baxter, Leslie C., Caselli, Richard J., & Wang, Yalin (2014). Genetic Influence of Apolipoprotein E4 Genotype on Hippocampal Morphometry: An N=725 Surface-Based Alzheimer's Disease Neuroimaging Initiative Study. HUMAN BRAIN MAPPING, 35(8), 3903-3918. http://dx.doi.org/10.1002/hbm.22447

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