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Lizards, which are amniote vertebrates like humans, are able to lose and regenerate a functional tail. Understanding the molecular basis of this process would advance regenerative approaches in amniotes, including

Lizards, which are amniote vertebrates like humans, are able to lose and regenerate a functional tail. Understanding the molecular basis of this process would advance regenerative approaches in amniotes, including humans. We have carried out the first transcriptomic analysis of tail regeneration in a lizard, the green anole Anolis carolinensis, which revealed 326 differentially expressed genes activating multiple developmental and repair mechanisms.

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    Date Created
    • 2014-08-20
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  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0105004
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Hutchins, Elizabeth D., Markov, Glenn J., Eckalbar, Walter L., George, Rajani M., King, Jesse M., Tokuyama, Minami A., Geiger, Lauren A., Emmert, Nataliya, Ammar, Michael J., Allen, April N., Siniard, Ashley L., Corneveaux, Jason J., Fisher, Rebecca E., Wade, Juli, DeNardo, Dale F., Rawls, J. Alan, Huentelman, Matthew J., Wilson-Rawls, Jeanne, & Kusumi, Kenro (2014). Transcriptomic Analysis of Tail Regeneration in the Lizard Anolis carolinensis Reveals Activation of Conserved Vertebrate Developmental and Repair Mechanisms. PLOS ONE, 9(8), e105004. http://dx.doi.org/10.1371/journal.pone.0105004

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