Description

DNA can be programmed to self-assemble into high molecular weight 3D assemblies with precise nanometer-scale structural features. Although numerous sequence design strategies exist to realize these assemblies in solution, there

DNA can be programmed to self-assemble into high molecular weight 3D assemblies with precise nanometer-scale structural features. Although numerous sequence design strategies exist to realize these assemblies in solution, there is currently no computational framework to predict their 3D structures on the basis of programmed underlying multi-way junction topologies constrained by DNA duplexes. Here, we introduce such an approach and apply it to assemblies designed using the canonical immobile four-way junction.

Reuse Permissions
  • application/pdf

    Download count: 0

    Details

    Contributors
    Date Created
    • 2014-12-01
    Resource Type
  • Text
  • Collections this item is in
    Identifier
    • Digital object identifier: 10.1038/ncomms6578
    • Identifier Type
      International standard serial number
      Identifier Value
      2041-1723
    Note

    Citation and reuse

    Cite this item

    This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.

    Pan, Keyao, Kim, Do-Nyun, Zhang, Fei, Adendorff, Matthew R., Yan, Hao, & Bathe, Mark (2014). Lattice-free prediction of three-dimensional structure of programmed DNA assemblies. NATURE COMMUNICATIONS, 5:5578. http://dx.doi.org/10.1038/ncomms6578

    Machine-readable links