DNA can be programmed to self-assemble into high molecular weight 3D assemblies with precise nanometer-scale structural features. Although numerous sequence design strategies exist to realize these assemblies in solution, there is currently no computational framework to predict their 3D structures on the basis of programmed underlying multi-way junction topologies constrained by DNA duplexes.
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- Pan, Keyao (Author)
- Kim, Do-Nyun (Author)
- Zhang, Fei (Author)
- Adendorff, Matthew R. (Author)
- Yan, Hao (Author)
- Bathe, Mark (Author)
- Biodesign Institute (Contributor)
- Digital object identifier: 10.1038/ncomms6578
- Identifier TypeInternational standard serial numberIdentifier Value2041-1723
- The final version of this article, as published in NATURE COMMUNICATIONS, can be viewed online at: http://dx.doi.org/10.1038/ncomms6578, opens in a new window
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Pan, Keyao, Kim, Do-Nyun, Zhang, Fei, Adendorff, Matthew R., Yan, Hao, & Bathe, Mark (2014). Lattice-free prediction of three-dimensional structure of programmed DNA assemblies. NATURE COMMUNICATIONS, 5:5578. http://dx.doi.org/10.1038/ncomms6578