Description

Collective cell migration plays a substantial role in maintaining the cohesion of epithelial cell layers and in wound healing. A number of mathematical models of this process have been developed,

Collective cell migration plays a substantial role in maintaining the cohesion of epithelial cell layers and in wound healing. A number of mathematical models of this process have been developed, all of which reduce to essentially a reaction-diffusion equation with diffusion and proliferation terms that depend on material assumptions about the cell layer. In this paper we extend a one-dimensional mathematical model of cell layer migration of Mi et al. [Biophys. J., 93 (2007), pp. 3745–3752] to incorporate stretch-dependent proliferation, and show that this formulation reduces to a generalized Stefan problem for the density of the layer. We solve numerically the resulting partial differential equation system using an adaptive finite difference method and show that the solutions converge to self-similar or traveling wave solutions. We analyze self-similar solutions for cases with no prolifera- tion, and necessary and sufficient conditions for existence and uniqueness of traveling solutions for a wide range of material assumptions about the cell layer.

Included in this item (4)



Details

Contributors
Agent
Date Created
  • 2013-11-30
Collections this item is in
Identifier
  • Digital object identifier: 10.1137/130941407
  • Identifier Type
    International standard serial number
    Identifier Value
    1536-0040

Citation and reuse

Machine-readable links