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We report a device to fill an array of small chemical reaction chambers (microreactors) with reagent and then seal them using pressurized viscous liquid acting through a flexible membrane. The

We report a device to fill an array of small chemical reaction chambers (microreactors) with reagent and then seal them using pressurized viscous liquid acting through a flexible membrane. The device enables multiple, independent chemical reactions involving free floating intermediate molecules without interference from neighboring reactions or external environments. The device is validated by protein expressed in situ directly from DNA in a microarray of ~10,000 spots with no diffusion during three hours incubation.

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    Date Created
    • 2015-03-04
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1038/srep08736
    • Identifier Type
      International standard serial number
      Identifier Value
      2045-2322
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    Wiktor, Peter, Brunner, Al, Kahn, Peter, Qiu, Ji, Magee, Mitch, Bian, Xiaofang, Karthikeyan, Kailash, & LaBaer, Joshua (2015). Microreactor Array Device. SCIENTIFIC REPORTS, 5.
    http://dx.doi.org/10.1038/srep08736

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