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Background
Overexpression and abnormal accumulation of aggregated α-synuclein (αS) have been linked to Parkinson's disease (PD) and other synucleinopathies. αS can misfold and adopt a variety of morphologies but recent

Background
Overexpression and abnormal accumulation of aggregated α-synuclein (αS) have been linked to Parkinson's disease (PD) and other synucleinopathies. αS can misfold and adopt a variety of morphologies but recent studies implicate oligomeric forms as the most cytotoxic species. Both genetic mutations and chronic exposure to neurotoxins increase αS aggregation and intracellular reactive oxygen species (ROS), leading to mitochondrial dysfunction and oxidative damage in PD cell models.
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    Date Created
    • 2010-04-30
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1186/1471-2202-11-57
    • Identifier Type
      International standard serial number
      Identifier Value
      1471-2202
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    Wang, M. S., Boddapati, S., Emadi, S., & Sierks, M. R. (2010). Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model. BMC Neuroscience, 11(1), 57. doi:10.1186/1471-2202-11-57

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