Background
Glioblastoma multiforme is a highly aggressive brain tumor with a poor prognosis, and advances in treatment have led to only marginal increases in overall survival. We and others have shown previously that the therapeutic ketogenic diet (KD) prolongs survival in mouse models of glioma, explained by both direct tumor growth inhibition and suppression of pro-inflammatory microenvironment conditions. The aim of this study is to assess the effects of the KD on the glioma reactive immune response.
Methods
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Details
- Lussier, Danielle (Contributor)
- Woolf, Eric (Contributor)
- Johnson, John (Contributor)
- Brooks, Kenneth S. (Author)
- Blattman, Joseph (Contributor)
- Scheck, Adrienne (Contributor)
- Immunotherapy, Vaccines and Virotherapy (Contributor)
- College of Liberal Arts and Sciences (Contributor)
- 2016-05-13
- Digital object identifier: 10.1186/s12885-016-2337-7
- Identifier TypeInternational standard serial numberIdentifier Value1471-2407
- The electronic version of this article is the complete one and can be found online at: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2337-7, opens in a new window
Citation and reuse
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This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.
Lussier, D. M., Woolf, E. C., Johnson, J. L., Brooks, K. S., Blattman, J. N., & Scheck, A. C. (2016). Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet. BMC Cancer, 16(1). doi:10.1186/s12885-016-2337-7