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Background
Salmonella has been employed to deliver therapeutic molecules against cancer and infectious diseases. As the carrier for target gene(s), the cargo plasmid should be stable in the bacterial vector.

Background
Salmonella has been employed to deliver therapeutic molecules against cancer and infectious diseases. As the carrier for target gene(s), the cargo plasmid should be stable in the bacterial vector. Plasmid recombination has been reduced in E. coli by mutating several genes including the recA, recE, recF and recJ. However, to our knowledge, there have been no published studies of the effect of these or any other genes that play a role in plasmid recombination in Salmonella enterica.
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    Date Created
    • 2011-02-08
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  • Text
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    Identifier
    • Digital object identifier: 10.1186/1471-2180-11-31
    • Identifier Type
      International standard serial number
      Identifier Value
      1471-2180
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    This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.

    Zhang, X., Wanda, S., Brenneman, K., Kong, W., Zhang, X., Roland, K., & Curtiss, R. (2011). Improving Salmonella vector with rec mutation to stabilize the DNA cargoes. BMC Microbiology, 11(1), 31. doi:10.1186/1471-2180-11-31

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