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  4. The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma
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The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma

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Description

Introduction: The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that alters metabolism by increasing the level of ketone bodies in the blood. KetoCal® (KC) is a nutritionally complete, commercially available 4∶1 (fat∶ carbohydrate+protein) ketogenic formula that is an effective non-pharmacologic treatment for the management of refractory pediatric epilepsy. Diet-induced ketosis causes changes to brain homeostasis that have potential for the treatment of other neurological diseases such as malignant gliomas.

Methods: We used an intracranial bioluminescent mouse model of malignant glioma. Following implantation animals were maintained on standard diet (SD) or KC. The mice received 2×4 Gy of whole brain radiation and tumor growth was followed by in vivo imaging.

Results: Animals fed KC had elevated levels of β-hydroxybutyrate (p = 0.0173) and an increased median survival of approximately 5 days relative to animals maintained on SD. KC plus radiation treatment were more than additive, and in 9 of 11 irradiated animals maintained on KC the bioluminescent signal from the tumor cells diminished below the level of detection (p<0.0001). Animals were switched to SD 101 days after implantation and no signs of tumor recurrence were seen for over 200 days.

Conclusions: KC significantly enhances the anti-tumor effect of radiation. This suggests that cellular metabolic alterations induced through KC may be useful as an adjuvant to the current standard of care for the treatment of human malignant gliomas.

Date Created
2012-05-01
Contributors
  • Abdelwahab, Mohammed G. (Author)
  • Fenton, Kathryn E. (Author)
  • Preul, Mark C. (Author)
  • Rho, Jong M. (Author)
  • Lynch, Andrew (Author)
  • Stafford, Phillip (Author)
  • Scheck, Adrienne C. (Author)
  • Biodesign Institute (Contributor)
Resource Type
Text
Extent
7 pages
Language
eng
Copyright Statement
In Copyright
Reuse Permissions
Attribution
Primary Member of
ASU Scholarship Showcase
Identifier
Digital object identifier: 10.1371/journal.pone.0036197
Identifier Type
International standard serial number
Identifier Value
1045-3830
Identifier Type
International standard serial number
Identifier Value
1939-1560
Peer-reviewed
No
Open Access
No
Series
PLOS ONE
Handle
https://hdl.handle.net/2286/R.I.42372
Preferred Citation

Abdelwahab, M. G., Fenton, K. E., Preul, M. C., Rho, J. M., Lynch, A., Stafford, P., & Scheck, A. C. (2012). The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma. PLoS ONE, 7(5). doi:10.1371/journal.pone.0036197

Level of coding
minimal
Cataloging Standards
asu1
Note
The article is published at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036197, opens in a new window
System Created
  • 2017-04-12 04:40:22
System Modified
  • 2021-12-03 04:08:10
  •     
  • 1 year 3 months ago
Additional Formats
  • OAI Dublin Core
  • MODS XML

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