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The low pH of the stomach serves as a barrier to ingested microbes and must be overcome or bypassed when delivering live bacteria for vaccine or probiotic applications. Typically, the

The low pH of the stomach serves as a barrier to ingested microbes and must be overcome or bypassed when delivering live bacteria for vaccine or probiotic applications. Typically, the impact of stomach acidity on bacterial survival is evaluated in vitro, as there are no small animal models to evaluate these effects in vivo. To better understand the effect of this low pH barrier to live attenuated Salmonella vaccines, which are often very sensitive to low pH, we investigated the value of the histamine mouse model for this application.

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    Date Created
    • 2014-01-29
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0087411
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Brenneman, K. E., Willingham, C., Kilbourne, J. A., 3Rd, R. C., & Roland, K. L. (2014). A Low Gastric pH Mouse Model to Evaluate Live Attenuated Bacterial Vaccines. PLoS ONE, 9(1). doi:10.1371/journal.pone.0087411

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