Description

Cyanovirin-N (CV-N) is an antiviral lectin with potent activity against enveloped viruses, including HIV. The mechanism of action involves high affinity binding to mannose-rich glycans that decorate the surface of

Cyanovirin-N (CV-N) is an antiviral lectin with potent activity against enveloped viruses, including HIV. The mechanism of action involves high affinity binding to mannose-rich glycans that decorate the surface of enveloped viruses. In the case of HIV, antiviral activity of CV-N is postulated to require multivalent interactions with envelope protein gp120, achieved through a pseudo-repeat of sequence that adopts two near-identical glycan-binding sites, and possibly involves a 3D-domain-swapped dimeric form of CV-N.

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    Date Created
    • 2016-06-06
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.3390/v8060158
    • Identifier Type
      International standard serial number
      Identifier Value
      1999-4915

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    Woodrum, B., Maxwell, J., Allen, D., Wilson, J., Krumpe, L., Bobkov, A., . . . Ghirlanda, G. (2016). A Designed “Nested” Dimer of Cyanovirin-N Increases Antiviral Activity. Viruses, 8(6), 158. doi:10.3390/v8060158

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