Background
Previous studies exploring sequence variation in the model legume, Medicago truncatula, relied on mapping short reads to a single reference. However, read-mapping approaches are inadequate to examine large, diverse gene families or to probe variation in repeat-rich or highly divergent genome regions. De novo sequencing and assembly of M. truncatula genomes enables near-comprehensive discovery of structural variants (SVs), analysis of rapidly evolving gene families, and ultimately, construction of a pan-genome.
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- Zhou, Peng (Author)
- Silverstein, Kevin A. T. (Author)
- Ramaraj, Thiruvarangan (Author)
- Guhlin, Joseph (Author)
- Denny, Roxanne (Author)
- Liu, Junqi (Author)
- Farmer, Andrew D. (Author)
- Steele, Kelly (Contributor)
- Stupar, Robert M. (Author)
- Miller, Jason R. (Author)
- Tiffin, Peter (Author)
- Mudge, Joann (Author)
- Young, Nevin D. (Author)
- New College of Interdisciplinary Arts and Sciences (Contributor)
- 2017-03-27
- Digital object identifier: 10.1186/s12864-017-3654-1
- Identifier TypeInternational standard serial numberIdentifier Value1471-2164
- The electronic version of this article is the complete one and can be found online at: https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3654-1, opens in a new window
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Zhou, P., Silverstein, K. A., Ramaraj, T., Guhlin, J., Denny, R., Liu, J., . . . Young, N. D. (2017). Exploring structural variation and gene family architecture with De Novo assemblies of 15 Medicago genomes. BMC Genomics, 18(1). doi:10.1186/s12864-017-3654-1