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Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been

Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis.

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    Date Created
    • 2016-07-21
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0159899
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Kim, S., Park, Y., Cho, S., Margalit, O., Wang, D., & Dubois, R. N. (2016). Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1. Plos One, 11(7). doi:10.1371/journal.pone.0159899

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