In women, high levels of natural progesterone have been associated with detrimental cognitive effects via the “maternal amnesia” phenomenon as well as in controlled experiments. In aged ovariectomized (Ovx) rats, progesterone has been shown to impair cognition and impact the GABAergic system in cognitive brain regions.

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    • Digital object identifier: 10.3389/fnagi.2015.00149
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    Braden, B. B., Kingston, M. L., Koenig, E. N., Lavery, C. N., Tsang, C. W., & Bimonte-Nelson, H. A. (2015). The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats. Frontiers in Aging Neuroscience, 7. doi:10.3389/fnagi.2015.00149

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