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In women, high levels of natural progesterone have been associated with detrimental cognitive effects via the “maternal amnesia” phenomenon as well as in controlled experiments. In aged ovariectomized (Ovx) rats,

In women, high levels of natural progesterone have been associated with detrimental cognitive effects via the “maternal amnesia” phenomenon as well as in controlled experiments. In aged ovariectomized (Ovx) rats, progesterone has been shown to impair cognition and impact the GABAergic system in cognitive brain regions. Here, we tested whether the GABAergic system is a mechanism of progesterone’s detrimental cognitive effects in the Ovx rat by attempting to reverse progesterone-induced impairments via concomitant treatment with the GABA[subscript A] antagonist, bicuculline.

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    Date Created
    • 2015-08-14
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.3389/fnagi.2015.00149
    • Identifier Type
      International standard serial number
      Identifier Value
      1663-4365

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    Braden, B. B., Kingston, M. L., Koenig, E. N., Lavery, C. N., Tsang, C. W., & Bimonte-Nelson, H. A. (2015). The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats. Frontiers in Aging Neuroscience, 7. doi:10.3389/fnagi.2015.00149

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