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  4. Modeling the Influence of Ion Channels on Neuron Dynamics in Drosophila
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Modeling the Influence of Ion Channels on Neuron Dynamics in Drosophila

Full metadata

Description

Voltage gated ion channels play a major role in determining a neuron's firing behavior, resulting in the specific processing of synaptic input patterns. Drosophila and other invertebrates provide valuable model systems for investigating ion channel kinetics and their impact on firing properties. Despite the increasing importance of Drosophila as a model system, few computational models of its ion channel kinetics have been developed. In this study, experimentally observed biophysical properties of voltage gated ion channels from the fruitfly Drosophila melanogaster are used to develop a minimal, conductance based neuron model. We investigate the impact of the densities of these channels on the excitability of the model neuron. Changing the channel densities reproduces different in situ observed firing patterns and induces a switch from integrator to resonator properties. Further, we analyze the preference to input frequency and how it depends on the channel densities and the resulting bifurcation type the system undergoes. An extension to a three dimensional model demonstrates that the inactivation kinetics of the sodium channels play an important role, allowing for firing patterns with a delayed first spike and subsequent high frequency firing as often observed in invertebrates, without altering the kinetics of the delayed rectifier current.

Date Created
2015-11-18
Contributors
  • Berger, Sandra (Author)
  • Crook, Sharon (Author)
  • College of Liberal Arts and Sciences (Contributor)
Resource Type
Text
Extent
20 pages
Language
eng
Copyright Statement
In Copyright
Reuse Permissions
Attribution
Primary Member of
ASU Scholarship Showcase
Identifier
Digital object identifier: 10.3389/fncom.2015.00139
Identifier Type
International standard serial number
Identifier Value
1662-5188
Peer-reviewed
No
Open Access
No
Series
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
Handle
https://hdl.handle.net/2286/R.I.43844
Preferred Citation

Berger, S. D., & Crook, S. M. (2015). Modeling the Influence of Ion Channels on Neuron Dynamics in Drosophila. Frontiers in Computational Neuroscience, 9. doi:10.3389/fncom.2015.00139

Level of coding
minimal
Cataloging Standards
asu1
Note
View the article as published at http://journal.frontiersin.org/article/10.3389/fncom.2015.00139/full, opens in a new window
System Created
  • 2017-05-24 02:32:08
System Modified
  • 2021-12-06 04:08:26
  •     
  • 1 year 3 months ago
Additional Formats
  • OAI Dublin Core
  • MODS XML

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