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Two distinct monocyte (Mo)/macrophage (Mp) subsets (Ly6C[superscript low] and Ly6C[superscript high]) orchestrate cardiac recovery process following myocardial infarction (MI). Prostaglandin (PG) E[subscript 2] is involved in the Mo/Mp-mediated inflammatory response,

Two distinct monocyte (Mo)/macrophage (Mp) subsets (Ly6C[superscript low] and Ly6C[superscript high]) orchestrate cardiac recovery process following myocardial infarction (MI). Prostaglandin (PG) E[subscript 2] is involved in the Mo/Mp-mediated inflammatory response, however, the role of its receptors in Mos/Mps in cardiac healing remains to be determined. Here we show that pharmacological inhibition or gene ablation of the Ep3 receptor in mice suppresses accumulation of Ly6C[superscript low] Mos/Mps in infarcted hearts.

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    Date Created
    • 2017-03-03
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    Identifier
    • Digital object identifier: 10.1038/ncomms14656
    • Identifier Type
      International standard serial number
      Identifier Value
      2041-1723
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    Tang, J., Shen, Y., Chen, G., Wan, Q., Wang, K., Zhang, J., . . . Yu, Y. (2017). Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nature Communications, 8, 14656. doi:10.1038/ncomms14656

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