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In vitro models that mimic in vivo host-pathogen interactions are needed to evaluate candidate drugs that inhibit bacterial virulence traits. We established a new approach to study Pseudomonas aeruginosa biofilm

In vitro models that mimic in vivo host-pathogen interactions are needed to evaluate candidate drugs that inhibit bacterial virulence traits. We established a new approach to study Pseudomonas aeruginosa biofilm susceptibility on biotic surfaces, using a three-dimensional (3-D) lung epithelial cell model. P. aeruginosa formed antibiotic resistant biofilms on 3-D cells without affecting cell viability.

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    Date Created
    • 2017-03-03
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  • Text
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    Identifier
    • Digital object identifier: 10.1038/srep43321
    • Identifier Type
      International standard serial number
      Identifier Value
      2045-2322
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    Crabbé, A., Liu, Y., Matthijs, N., Rigole, P., Fuente-Nùñez, C. D., Davis, R., . . . Nickerson, C. A. (2017). Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum. Scientific Reports, 7, 43321. doi:10.1038/srep43321

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