In vitro models that mimic in vivo host-pathogen interactions are needed to evaluate candidate drugs that inhibit bacterial virulence traits. We established a new approach to study Pseudomonas aeruginosa biofilm susceptibility on biotic surfaces, using a three-dimensional (3-D) lung epithelial cell model. P. aeruginosa formed antibiotic resistant biofilms on 3-D cells without affecting cell viability.
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- Crabbe, Aurelie (Contributor)
- Liu, Yulong (Contributor)
- Matthijs, Nele (Author)
- Rigole, Petra (Author)
- De La Fuente-Nunez, Cesar (Author)
- Davis, Richard (Contributor)
- Ledesma, Maria (Contributor)
- Sarker, Shameema (Contributor)
- Van Houdt, Rob (Author)
- Hancock, Robert E. W. (Author)
- Coenye, Tom (Author)
- Nickerson, Cheryl (Contributor)
- Immunotherapy, Vaccines and Virotherapy (Contributor)
- Biodesign Institute (Contributor)
- 2017-03-03
- Digital object identifier: 10.1038/srep43321
- Identifier TypeInternational standard serial numberIdentifier Value2045-2322
- The final version of this article, as published in Scientific Reports, can be viewed online at: http://www.nature.com/articles/srep43321, opens in a new window
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Crabbé, A., Liu, Y., Matthijs, N., Rigole, P., Fuente-Nùñez, C. D., Davis, R., . . . Nickerson, C. A. (2017). Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum. Scientific Reports, 7, 43321. doi:10.1038/srep43321