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Mechanical interactions between cells and their microenvironment dictate cell phenotype and behavior, calling for cell mechanics measurements in three-dimensional (3D) extracellular matrices (ECM). Here we describe a novel technique for quantitative mechanical characterization of soft, heterogeneous samples in 3D.

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    Date Created
    2016-01-27
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    Identifier
    • Digital object identifier: 10.1038/srep19686
    • Identifier Type
      International standard serial number
      Identifier Value
      2045-2322
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    Staunton, J. R., Doss, B. L., Lindsay, S., & Ros, R. (2016). Correlating confocal microscopy and atomic force indentation reveals metastatic cancer cells stiffen during invasion into collagen I matrices. Scientific Reports, 6(1). doi:10.1038/srep19686

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