Description
Mechanical interactions between cells and their microenvironment dictate cell phenotype and behavior, calling for cell mechanics measurements in three-dimensional (3D) extracellular matrices (ECM). Here we describe a novel technique for quantitative mechanical characterization of soft, heterogeneous samples in 3D.
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Contributors
- Staunton, Jack (Author)
- Doss, Bryant (Author)
- Lindsay, Stuart (Author)
- Ros, Robert (Author)
- College of Liberal Arts and Sciences (Contributor)
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2016-01-27
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Identifier
- Digital object identifier: 10.1038/srep19686
- Identifier TypeInternational standard serial numberIdentifier Value2045-2322
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- The final version of this article, as published in Scientific Reports, can be viewed online at: https://www.nature.com/articles/srep19686, opens in a new window
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Staunton, J. R., Doss, B. L., Lindsay, S., & Ros, R. (2016). Correlating confocal microscopy and atomic force indentation reveals metastatic cancer cells stiffen during invasion into collagen I matrices. Scientific Reports, 6(1). doi:10.1038/srep19686