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Memory loss is the most profound clinical manifestation in Alzheimer’s disease (AD); however, the molecular mechanisms underlying these deficits are poorly understood. Identification of the molecular pathways involved in the

Memory loss is the most profound clinical manifestation in Alzheimer’s disease (AD); however, the molecular mechanisms underlying these deficits are poorly understood. Identification of the molecular pathways involved in the onset of cognitive deficits may lead to the identification of key events in the pathogenesis of AD. Using isobaric tags for relative and absolute quantitation (iTRAQ) and proteomic methods, here we identified learning-induced changes in the hippocampal proteome of non-transgenic (NonTg) and 3 × Tg-AD mice, a widely used animal model of AD.

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    Date Created
    • 2016-07-05
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    Identifier
    • Digital object identifier: 10.1038/tp.2016.114
    • Identifier Type
      International standard serial number
      Identifier Value
      2158-3188
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    Ferreira, E., Shaw, D. M., & Oddo, S. (2016). Identification of learning-induced changes in protein networks in the hippocampi of a mouse model of Alzheimer’s disease. Translational Psychiatry, 6(7). doi:10.1038/tp.2016.114

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