Aortic valve (AV) calcification is an inflammation driven process that occurs preferentially in the fibrosa. To explore the underlying mechanisms, we investigated if key microRNAs (miRNA) in the AV are differentially expressed due to disturbed blood flow (oscillatory shear (OS)) experienced by the fibrosa compared to the ventricularis.
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- Digital object identifier: 10.1038/srep25397
- Identifier TypeInternational standard serial numberIdentifier Value2045-2322
- The final version of this article, as published in Scientific Reports, can be viewed online at: https://www.nature.com/articles/srep25397, opens in a new window
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Rathan, S., Ankeny, C. J., Arjunon, S., Ferdous, Z., Kumar, S., Esmerats, J. F., . . . Jo, H. (2016). Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis. Scientific Reports, 6(1). doi:10.1038/srep25397