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Aortic valve (AV) calcification is an inflammation driven process that occurs preferentially in the fibrosa. To explore the underlying mechanisms, we investigated if key microRNAs (miRNA) in the AV are

Aortic valve (AV) calcification is an inflammation driven process that occurs preferentially in the fibrosa. To explore the underlying mechanisms, we investigated if key microRNAs (miRNA) in the AV are differentially expressed due to disturbed blood flow (oscillatory shear (OS)) experienced by the fibrosa compared to the ventricularis. To identify the miRNAs involved, endothelial-enriched RNA was isolated from either side of healthy porcine AVs for microarray analysis.

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    Date Created
    • 2016-05-06
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    Identifier
    • Digital object identifier: 10.1038/srep25397
    • Identifier Type
      International standard serial number
      Identifier Value
      2045-2322
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    Rathan, S., Ankeny, C. J., Arjunon, S., Ferdous, Z., Kumar, S., Esmerats, J. F., . . . Jo, H. (2016). Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis. Scientific Reports, 6(1). doi:10.1038/srep25397

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