Aortic valve (AV) calcification is an inflammation driven process that occurs preferentially in the fibrosa. To explore the underlying mechanisms, we investigated if key microRNAs (miRNA) in the AV are differentially expressed due to disturbed blood flow (oscillatory shear (OS)) experienced by the fibrosa compared to the ventricularis.

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    Rathan, S., Ankeny, C. J., Arjunon, S., Ferdous, Z., Kumar, S., Esmerats, J. F., . . . Jo, H. (2016). Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis. Scientific Reports, 6(1). doi:10.1038/srep25397

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