Outer membrane vesicles (OMVs) isolated from Salmonella Typhimurium are potentially useful for developing subunit vaccines because of high immunogenicity and protective efficacy. However, flagella might remain in OMV pellets following OMV purification, resulting in non-essential immune responses and counteraction of bacterial protective immune responses when developing a vaccine against infection of multiple serotypes Salmonella. In this study, a flagellin-deficient S. Typhimurium mutant was constructed.
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- Liu, Qiong (Contributor)
- Liu, Qing (Author)
- Yi, Jie (Author)
- Liang, Kang (Author)
- Hu, Bo (Author)
- Zhang, Xiangmin (Author)
- Curtiss, Roy (Contributor)
- Kong, Qingke (Contributor)
- Immunotherapy, Vaccines and Virotherapy (Contributor)
- Biodesign Institute (Contributor)
- 2016-10-04
- Digital object identifier: 10.1038/srep34776
- Identifier TypeInternational standard serial numberIdentifier Value2045-2322
- The final version of this article, as published in Scientific Reports, can be viewed online at: http://www.nature.com/articles/srep34776, opens in a new window
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Liu, Q., Liu, Q., Yi, J., Liang, K., Hu, B., Zhang, X., . . . Kong, Q. (2016). Outer membrane vesicles from flagellin-deficient Salmonella enterica serovar Typhimurium induce cross-reactive immunity and provide cross-protection against heterologous Salmonella challenge. Scientific Reports, 6(1). doi:10.1038/srep34776