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Outer membrane vesicles (OMVs) isolated from Salmonella Typhimurium are potentially useful for developing subunit vaccines because of high immunogenicity and protective efficacy. However, flagella might remain in OMV pellets following

Outer membrane vesicles (OMVs) isolated from Salmonella Typhimurium are potentially useful for developing subunit vaccines because of high immunogenicity and protective efficacy. However, flagella might remain in OMV pellets following OMV purification, resulting in non-essential immune responses and counteraction of bacterial protective immune responses when developing a vaccine against infection of multiple serotypes Salmonella. In this study, a flagellin-deficient S. Typhimurium mutant was constructed.

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    Date Created
    • 2016-10-04
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  • Text
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    Identifier
    • Digital object identifier: 10.1038/srep34776
    • Identifier Type
      International standard serial number
      Identifier Value
      2045-2322
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    Liu, Q., Liu, Q., Yi, J., Liang, K., Hu, B., Zhang, X., . . . Kong, Q. (2016). Outer membrane vesicles from flagellin-deficient Salmonella enterica serovar Typhimurium induce cross-reactive immunity and provide cross-protection against heterologous Salmonella challenge. Scientific Reports, 6(1). doi:10.1038/srep34776

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