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Functional and molecular cell-to-cell variability is pivotal at the cellular, tissue and whole-organism levels. Yet, the ultimate goal of directly correlating the function of the individual cell with its biomolecular

Functional and molecular cell-to-cell variability is pivotal at the cellular, tissue and whole-organism levels. Yet, the ultimate goal of directly correlating the function of the individual cell with its biomolecular profile remains elusive. We present a platform for integrated analysis of functional and transcriptional phenotypes in the same single cells. We investigated changes in the cellular respiration and gene expression diversity resulting from adaptation to repeated episodes of acute hypoxia in a premalignant progression model.

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    Date Created
    • 2017-03-16
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  • Text
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    Identifier
    • Digital object identifier: 10.1038/srep44636
    • Identifier Type
      International standard serial number
      Identifier Value
      2045-2322
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    Kelbauskas, L., Ashili, S., Zeng, J., Rezaie, A., Lee, K., Derkach, D., . . . Meldrum, D. R. (2017). Platform for combined analysis of functional and biomolecular phenotypes of the same cell. Scientific Reports, 7, 44636. doi:10.1038/srep44636

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