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Enzymes in biology’s energy chains operate with low energy input distributed through multiple electron transfer steps between protein active sites. The general challenge of biological design is how to lower

Enzymes in biology’s energy chains operate with low energy input distributed through multiple electron transfer steps between protein active sites. The general challenge of biological design is how to lower the activation barrier without sacrificing a large negative reaction free energy. We show that this goal is achieved through a large polarizability of the active site. It is polarized by allowing a large number of excited states, which are populated quantum mechanically by electrostatic fluctuations of the protein and hydration water shells.

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    Date Created
    • 2016-06-16
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    Identifier
    • Digital object identifier: 10.1038/srep28152
    • Identifier Type
      International standard serial number
      Identifier Value
      2045-2322
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    Dinpajooh, M., Martin, D. R., & Matyushov, D. V. (2016). Polarizability of the active site of cytochrome c reduces the activation barrier for electron transfer. Scientific Reports, 6(1). doi:10.1038/srep28152

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