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Telomerase emerged during evolution as a prominent solution to the eukaryotic linear chromosome end-replication problem. Telomerase minimally comprises the catalytic telomerase reverse transcriptase (TERT) and telomerase RNA (TR) that provides

Telomerase emerged during evolution as a prominent solution to the eukaryotic linear chromosome end-replication problem. Telomerase minimally comprises the catalytic telomerase reverse transcriptase (TERT) and telomerase RNA (TR) that provides the template for telomeric DNA synthesis. While the TERT protein is well-conserved across taxa, TR is highly divergent amongst distinct groups of species.

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    Date Created
    • 2016-07-04
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    Identifier
    • Digital object identifier: 10.1093/nar/gkw605
    • Identifier Type
      International standard serial number
      Identifier Value
      1362-4962
    • Identifier Type
      International standard serial number
      Identifier Value
      0305-1048
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    Podlevsky, J. D., Li, Y., & Chen, J. J. (2016). The functional requirement of two structural domains within telomerase RNA emerged early in eukaryotes. Nucleic Acids Research. doi:10.1093/nar/gkw605

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