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Secreted ligands in the Dpp/BMP family drive dorsal–ventral (D/V) axis formation in all Bilaterian species. However, maternal factors regulating Dpp/BMP transcription in this process are largely unknown. We identified the

Secreted ligands in the Dpp/BMP family drive dorsal–ventral (D/V) axis formation in all Bilaterian species. However, maternal factors regulating Dpp/BMP transcription in this process are largely unknown. We identified the BTB domain protein longitudinals lacking-like (lolal) as a modifier of decapentaplegic (dpp) mutations. We show that Lolal is evolutionarily related to the Trithorax group of chromatin regulators and that lolal interacts genetically with the epigenetic factor Trithorax-like during Dpp D/V signaling.

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    Date Created
    • 2016-07-08
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    Identifier
    • Digital object identifier: 10.1093/molbev/msw132
    • Identifier Type
      International standard serial number
      Identifier Value
      1537-1719
    • Identifier Type
      International standard serial number
      Identifier Value
      0737-4038
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    Quijano, J. C., Wisotzkey, R. G., Tran, N. L., Huang, Y., Stinchfield, M. J., Haerry, T. E., . . . Newfeld, S. J. (2016). Iolal is an Evolutionarily New Epigenetic Regulator ofdppTranscription during Dorsal–Ventral Axis Formation. Molecular Biology and Evolution, 33(10), 2621-2632. doi:10.1093/molbev/msw132

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