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Male mutation bias, when more mutations are passed on via the male germline than via the female germline, is observed across mammals. One common way to infer the magnitude of

Male mutation bias, when more mutations are passed on via the male germline than via the female germline, is observed across mammals. One common way to infer the magnitude of male mutation bias, α, is to compare levels of neutral sequence divergence between genomic regions that spend different amounts of time in the male and female germline. For great apes, including human, we show that estimates of divergence are reduced in putatively unconstrained regions near genes relative to unconstrained regions far from genes.

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    Date Created
    • 2016-11-09
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    Identifier
    • Digital object identifier: 10.1093/gbe/evw232
    • Identifier Type
      International standard serial number
      Identifier Value
      1759-6653
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    Narang, P., & Sayres, M. A. (2016). Variable Autosomal and X Divergence Near and Far from Genes Affects Estimates of Male Mutation Bias in Great Apes. Genome Biology and Evolution, 8(11), 3393-3405. doi:10.1093/gbe/evw232

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