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The single-span membrane protein KCNE3 modulates a variety of voltage-gated ion channels in diverse biological contexts. In epithelial cells, KCNE3 regulates the function of the KCNQ1 potassium ion (K[superscript +])

The single-span membrane protein KCNE3 modulates a variety of voltage-gated ion channels in diverse biological contexts. In epithelial cells, KCNE3 regulates the function of the KCNQ1 potassium ion (K[superscript +]) channel to enable K[superscript +] recycling coupled to transepithelial chloride ion (Cl[superscript −]) secretion, a physiologically critical cellular transport process in various organs and whose malfunction causes diseases, such as cystic fibrosis (CF), cholera, and pulmonary edema.

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    • 2016-09-09
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    Kroncke, B. M., Horn, W. D., Smith, J., Kang, C., Welch, R. C., Song, Y., . . . Sanders, C. R. (2016). Structural basis for KCNE3 modulation of potassium recycling in epithelia. Science Advances, 2(9). doi:10.1126/sciadv.1501228

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