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In eutherians, the placenta acts as a barrier and conduit at the maternal-fetal interface. Syncytiotrophoblasts, the multinucleated cells that cover the placental villous tree surfaces of the human placenta, are

In eutherians, the placenta acts as a barrier and conduit at the maternal-fetal interface. Syncytiotrophoblasts, the multinucleated cells that cover the placental villous tree surfaces of the human placenta, are directly bathed in maternal blood and are formed by the fusion of progenitor cytotrophoblasts that underlie them. Despite their crucial role in fetal protection, many of the events that govern trophoblast fusion and protection from microbial infection are unknown.

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    Date Created
    • 2016-03-04
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  • Text
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    Identifier
    • Digital object identifier: 10.1126/sciadv.1501462
    • Identifier Type
      International standard serial number
      Identifier Value
      2375-2548

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    Mcconkey, C. A., Delorme-Axford, E., Nickerson, C. A., Kim, K. S., Sadovsky, Y., Boyle, J. P., & Coyne, C. B. (2016). A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance. Science Advances, 2(3). doi:10.1126/sciadv.1501462

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