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MicroRNAs (miRNAs) regulate gene output by targeting degenerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes. The evolutionary advantage of maintaining copies of highly similar miRNAs

MicroRNAs (miRNAs) regulate gene output by targeting degenerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes. The evolutionary advantage of maintaining copies of highly similar miRNAs is not well understood, nor is it clear what unique functions, if any, miRNA family members possess. Here, we study evolutionary patterns of metazoan miRNAs, focusing on the targeting preferences of the let-7 and miR-10 families. These studies reveal hotspots for sequence evolution with implications for targeting and secondary structure.

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    Date Created
    • 2016-12-07
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1101/gr.209361.116
    • Identifier Type
      International standard serial number
      Identifier Value
      1088-9051
    • Identifier Type
      International standard serial number
      Identifier Value
      1549-5469
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    Wolter, J. M., Le, H. H., Linse, A., Godlove, V. A., Nguyen, T., Kotagama, K., . . . Mangone, M. (2016). Evolutionary patterns of metazoan microRNAs reveal targeting principles in the let-7 and miR-10 families. Genome Research, 27(1), 53-63. doi:10.1101/gr.209361.116

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