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Clear cell renal cell carcinomas (ccRCCs) harbor frequent mutations in epigenetic modifiers including SETD2, the H3K36me3 writer. We profiled DNA methylation (5mC) across the genome in cell line-based models of

Clear cell renal cell carcinomas (ccRCCs) harbor frequent mutations in epigenetic modifiers including SETD2, the H3K36me3 writer. We profiled DNA methylation (5mC) across the genome in cell line-based models of SETD2 inactivation and SETD2 mutant primary tumors because 5mC has been linked to H3K36me3 and is therapeutically targetable.

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    Date Created
    • 2015-12-05
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    Identifier
    • Digital object identifier: 10.18632/oncotarget.6481
    • Identifier Type
      International standard serial number
      Identifier Value
      1949-2553
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    Tiedemann, R. L., Hlady, R. A., Hanavan, P. D., Lake, D. F., Tibes, R., Lee, J., . . . Robertson, K. D. (2016). Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma. Oncotarget. doi:10.18632/oncotarget.6481

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