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We used DNA content flow cytometry followed by oligonucleotide array based comparative genomic hybridization to survey the genomes of 326 tumors, including 41 untreated surgically resected triple negative breast cancers

We used DNA content flow cytometry followed by oligonucleotide array based comparative genomic hybridization to survey the genomes of 326 tumors, including 41 untreated surgically resected triple negative breast cancers (TNBC). A high level (log2ratio ≥1) 9p24 amplicon was found in TNBC (12/41), glioblastomas (2/44), and colon carcinomas (2/68). The shortest region of overlap for the amplicon targets 9p24.1 and includes the loci for PD-L1, PD-L2, and JAK2 (PDJ amplicon).

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    Date Created
    • 2015-07-03
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.18632/oncotarget.4494
    • Identifier Type
      International standard serial number
      Identifier Value
      1949-2553
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    Barrett, M. T., Anderson, K. S., Lenkiewicz, E., Andreozzi, M., Cunliffe, H. E., Klassen, C. L., . . . Pockaj, B. A. (2015). Genomic amplification of 9p24.1 targetingJAK2, PD-L1,andPD-L2is enriched in high-risk triple negative breast cancer. Oncotarget, 6(28), 26483-26493. doi:10.18632/oncotarget.4494

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