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EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews

EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis. We then discuss the signaling pathways and the differential expression and down-regulation of receptors in both tumor cells and stromal cells, which play a role in EMT and metastasis.

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    Date Created
    • 2015-02-26
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1186/s40169-015-0048-3
    • Identifier Type
      International standard serial number
      Identifier Value
      2001-1326
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    Heerboth, S., Housman, G., Leary, M., Longacre, M., Byler, S., Lapinska, K., . . . Sarkar, S. (2015). EMT and tumor metastasis. Clinical and Translational Medicine, 4(1). doi:10.1186/s40169-015-0048-3

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