Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to disease, including infectious diseases. To evaluate the potential impact of the spaceflight environment on the regulation of molecular pathways mediating cellular stress responses, we performed a first-of-its-kind pilot study to assess spaceflight-related gene-expression changes in the whole blood of astronauts.
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- Barrila, Jennifer (Contributor)
- Ott, C. Mark (Author)
- LeBlanc, Carly (Author)
- Mehta, Satish K. (Author)
- Crabbe, Aurelie (Contributor)
- Stafford, Phillip (Contributor)
- Pierson, Duane L. (Author)
- Nickerson, Cheryl (Contributor)
- Immunotherapy, Vaccines and Virotherapy (Contributor)
- Biodesign Institute (Contributor)
- 2016-12-08
- Digital object identifier: 10.1038/npjmgrav.2016.39
- Identifier TypeInternational standard serial numberIdentifier Value2373-8065
- The final version of this article, as published in Npj Microgravity, can be viewed online at: http://www.nature.com/articles/npjmgrav201639, opens in a new window
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Barrila, J., Ott, C. M., Leblanc, C., Mehta, S. K., Crabbé, A., Stafford, P., . . . Nickerson, C. A. (2016). Spaceflight modulates gene expression in the whole blood of astronauts. Npj Microgravity, 2(1). doi:10.1038/npjmgrav.2016.39