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There is an urgent need for the development of new therapeutic strategies for Alzheimer's disease (AD). The dual-specificity tyrosine phosphorylation-regulated kinase-1A (Dyrk1a) is a protein kinase that phosphorylates the amyloid

There is an urgent need for the development of new therapeutic strategies for Alzheimer's disease (AD). The dual-specificity tyrosine phosphorylation-regulated kinase-1A (Dyrk1a) is a protein kinase that phosphorylates the amyloid precursor protein (APP) and tau and thus represents a link between two key proteins involved in AD pathogenesis. Furthermore, Dyrk1a is upregulated in postmortem human brains, and high levels of Dyrk1a are associated with mental retardation.

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    Date Created
    • 2017-06-19
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  • Text
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    Identifier
    • Digital object identifier: 10.1111/acel.12648
    • Identifier Type
      International standard serial number
      Identifier Value
      1474-9718
    • Identifier Type
      International standard serial number
      Identifier Value
      1474-9726
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    Branca, C., Shaw, D. M., Belfiore, R., Gokhale, V., Shaw, A. Y., Foley, C., . . . Oddo, S. (2017). Dyrk1 inhibition improves Alzheimers disease-like pathology. Aging Cell. doi:10.1111/acel.12648

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