We have previously shown that the diversity of antibodies in an individual can be displayed on chips on which 130,000 peptides chosen from random sequence space have been synthesized. This immunosignature technology is unbiased in displaying antibody diversity relative to natural sequence space, and has been shown to have diagnostic and prognostic potential for a wide variety of diseases and vaccines. Here we show that a global measure such as Shannon’s entropy can be calculated for each immunosignature.
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- Digital object identifier: 10.1038/s41598-017-18469-6
- Identifier TypeInternational standard serial numberIdentifier Value2045-2322
- The final version of this article, as published in Scientific Reports, can be viewed online at: http://www.nature.com/articles/s41598-017-18469-6, opens in a new window
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Wang, L., Whittemore, K., Johnston, S. A., & Stafford, P. (2017). Entropy is a Simple Measure of the Antibody Profile and is an Indicator of Health Status: A Proof of Concept. Scientific Reports, 7(1). doi:10.1038/s41598-017-18469-6