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The process, how lipids are removed from the circulation and transferred from high density lipoprotein (HDL) – a main carrier of cholesterol in the blood stream – to cells, is

The process, how lipids are removed from the circulation and transferred from high density lipoprotein (HDL) – a main carrier of cholesterol in the blood stream – to cells, is highly complex. HDL particles are captured from the blood stream by the scavenger receptor, class B, type I (SR-BI), the so-called HDL receptor. The details in subsequent lipid-transfer process, however, have not yet been completely understood. The transfer has been proposed to occur directly at the cell surface across an unstirred water layer, via a hydrophobic channel in the receptor, or after HDL endocytosis.

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    Date Created
    • 2017-11-21
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  • Text
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    Identifier
    • Digital object identifier: 10.1038/s41598-017-15949-7
    • Identifier Type
      International standard serial number
      Identifier Value
      2045-2322
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    Plochberger, B., Röhrl, C., Preiner, J., Rankl, C., Brameshuber, M., Madl, J., . . . Schütz, G. J. (2017). HDL particles incorporate into lipid bilayers – a combined AFM and single molecule fluorescence microscopy study. Scientific Reports, 7(1). doi:10.1038/s41598-017-15949-7

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