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Tissue engineering aims to utilise biologic mediators to facilitate tissue regeneration. Several recombinant proteins have potential to mediate induction of bone production, however, the high production cost of mammalian cell

Tissue engineering aims to utilise biologic mediators to facilitate tissue regeneration. Several recombinant proteins have potential to mediate induction of bone production, however, the high production cost of mammalian cell expression impedes patient access to such treatments. The aim of this study is to produce recombinant human osteopontin (hOPN) in plants for inducing dental bone regeneration. The expression host was Nicotiana benthamiana using a geminiviral vector for transient expression.

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    Date Created
    • 2017-12-11
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  • Text
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    • Digital object identifier: 10.1038/s41598-017-17666-7
    • Identifier Type
      International standard serial number
      Identifier Value
      2045-2322
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    Rattanapisit, K., Abdulheem, S., Chaikeawkaew, D., Kubera, A., Mason, H. S., Ma, J. K., . . . Phoolcharoen, W. (2017). Recombinant human osteopontin expressed in Nicotiana benthamiana stimulates osteogenesis related genes in human periodontal ligament cells. Scientific Reports, 7(1). doi:10.1038/s41598-017-17666-7

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