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Agassiz’s desert tortoise (Gopherus agassizii) is a long-lived species native to the Mojave Desert and is listed as threatened under the US Endangered Species Act. To aid conservation efforts for preserving the genetic diversity of this species, we generated a whole genome reference sequence with an annotation based on dee

Agassiz’s desert tortoise (Gopherus agassizii) is a long-lived species native to the Mojave Desert and is listed as threatened under the US Endangered Species Act. To aid conservation efforts for preserving the genetic diversity of this species, we generated a whole genome reference sequence with an annotation based on deep transcriptome sequences of adult skeletal muscle, lung, brain, and blood. The draft genome assembly for G. agassizii has a scaffold N50 length of 252 kbp and a total length of 2.4 Gbp. Genome annotation reveals 20,172 protein-coding genes in the G. agassizii assembly, and that gene structure is more similar to chicken than other turtles. We provide a series of comparative analyses demonstrating (1) that turtles are among the slowest-evolving genome-enabled reptiles, (2) amino acid changes in genes controlling desert tortoise traits such as shell development, longevity and osmoregulation, and (3) fixed variants across the Gopherus species complex in genes related to desert adaptations, including circadian rhythm and innate immune response. This G. agassizii genome reference and annotation is the first such resource for any tortoise, and will serve as a foundation for future analysis of the genetic basis of adaptations to the desert environment, allow for investigation into genomic factors affecting tortoise health, disease and longevity, and serve as a valuable resource for additional studies in this species complex.

Data Availability: All genomic and transcriptomic sequence files are available from the NIH-NCBI BioProject database (accession numbers PRJNA352725, PRJNA352726, and PRJNA281763). All genome assembly, transcriptome assembly, predicted protein, transcript, genome annotation, repeatmasker, phylogenetic trees, .vcf and GO enrichment files are available on Harvard Dataverse (doi:10.7910/DVN/EH2S9K).

ContributorsTollis, Marc (Author) / DeNardo, Dale F (Author) / Cornelius, John A (Author) / Dolby, Greer A (Author) / Edwards, Taylor (Author) / Henen, Brian T. (Author) / Karl, Alice E. (Author) / Murphy, Robert W. (Author) / Kusumi, Kenro (Author)
Created2017-05-31
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Description

Students in Organic Chemistry for Majors were required to write a paper as the culminating course assignment. Prior to completing this assignment, students could attend a library instruction session covering relevant databases and resources. Upon submission of their papers, bibliographies from 53 students were collected. Calculations were made to attempt

Students in Organic Chemistry for Majors were required to write a paper as the culminating course assignment. Prior to completing this assignment, students could attend a library instruction session covering relevant databases and resources. Upon submission of their papers, bibliographies from 53 students were collected. Calculations were made to attempt a holistic account of costs associated with completing the assignment. Factors such as the cost of journals, databases, and librarian time were all included in the overall cost estimate, totalling $7,189.22 for this single assignment.

ContributorsKromer, John (Author)
Created2019-07-02
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Description

Arizona State University is embracing new ways of thinking about how open stacks can make books active objects of engagement for a new generation of students, rather than risk becoming mere backdrops for study spaces. By taking a deliberate design approach to answering the question of which books and where,

Arizona State University is embracing new ways of thinking about how open stacks can make books active objects of engagement for a new generation of students, rather than risk becoming mere backdrops for study spaces. By taking a deliberate design approach to answering the question of which books and where, ASU Library seeks to position print collections as an engagement mechanism. This chapter presents the transformative potential of open stacks, along with planning for access, assessment and inclusive engagement. The authors describe how ASU Library is using a major library renovation project as a catalyst to explore these ideas, and propose a pathway to developing shared solutions for more effective use of library collections.

ContributorsMcAllister, Lorrie (Author) / Laster, Shari (Author) / Meyer, Lars (Editor)
Created2018